OFFICE 
Affiliation: Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University
Address: Kita-15 Nishi-7 Kita-Ku, Sapporo, 060-0815, Japan
Phone:  +81-11-706-5530
FAX    :  +81-11-706-7544
Email :  skita☆igm.hokudai.ac.jp (☆→@)
Current Position: Postdoctoral Fellow

Montserrat @ Spain    

POSITIONS HELD
2011- 2012 : JSPS Research Fellow (DC1), Kagoshima University
                       Graduate School of Medical and Dental Sciences
2012- date  : JSPS Research Fellow (PD), Hokkaido University
                        Institute for Genetic Medicine Division of Molecular Oncology

EDUCATION
2000-2004: Bachelor of Engineering, Faculty of engineering, Kagoshima University, Japan

2004-2006: Master of Science, Graduate School of Science and Engineering,  Kagoshima University, Japan
2009- 2012: Ph.D., Graduate School of Medical and Dental Sciences,  Kagoshima University, Japan

MEMBERSHIP IN PROFESSIONAL SOCIETIES
2010- date : The American Association for Cancer Research 
2010- date : The Japanese Cancer Association
2005- date : The Japanese Biochemical Society

RESEARCH INTERESTS
Cancer Biology, Epigenetics, Protein Engineering, Display technology (Phage), Immunology, Virology, Glycobiology

Original Articles
Yukihiro Tamura, Michiyo Higashi, Sho Kitamoto, Seiya Yokoyama, Masahiko Osako, Michiko Horinouchi, Takeshi Shimizu, Mineo Tabata, Surinder K. Batra, Masamichi Goto, Suguru Yonezawa; MUC4 and MUC1 Expression in Adenocarcinoma of the Stomach Correlates with Vessel Invasion and Lymph Node Metastasis: An Immunohistochemical Study of Early Gastric Cancer. PLoS ONE, in press, DOI: 10.1371/journal.pone.0049251, PMID: 23152882

Sho Kitamoto, Seiya Yokoyama, Michiyo Higashi, Norishige Yamada, Sonshin Takao, Suguru Yonezawa; MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. Oncogene, in press, DOI: 10.1038/onc.2012.478, PMID: 23108411

Sho Kitamoto, Seiya Yokoyama, Michiyo Higashi, Norishige Yamada, Shyuichiro Matsubara, Sonshin Takao, Surinder K. Batra, Suguru Yonezawa; Expression of MUC17 Is Regulated by HIF1α-mediated Hypoxic Responses and Requires a Methylation-free Hypoxia Responsible Element in Pancreatic Cancer. PLoS ONE, 7(9), 2012, DOI: 10.1371/journal.pone.0044108, PMID: 22970168

Hiroko Nagao, Takao Setoguchi, Sho Kitamoto, Yasuhiro Ishidou, Satoshi Nagano, Masahiro Yokouchi, Masahiko Abematsu, Naoya Kawabata, Shingo Maeda, Suguru Yonezawa, Setsuro Komiya; RBPJ Is a Novel Target for Rhabdomyosarcoma Therapy. PLoS ONE, 7(7), 2012, DOI: 10.1371/journal.pone.0039268, PMID: 22792167

Seiya Yokoyama, Sho Kitamoto, Norishige Yamada, Izumi Houjou, Tamotsu Sugai, Shin-ichi Nakamura, Yoshifumi Arisaka, Kyoichi Takaori, Michiyo Higashi and Suguru Yonezawa; The application of Methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5’ CpG island of mucin in cancer cells. BMC Cancer, 12 (1): 67, 2012, DOI: 10.1186/1471-2407-12-67, PMID: 22329852

Satoshi Nagata, Tomofumi Hamada, Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Yuji Kanmura, Masahiro Nomura, Yoshiaki Kamikawa, Suguru Yonezawa, Kazumasa Sugihara: Aberrant DNA methylation of tumor-related genes in oral rinse; A noninvasive method for detection of oral squamous cell carcinoma. Cancer, 118(17):4298-308, 2012, DOI: 10.1002/cncr.27417, PMID: 22252571

Suguru Yonezawa, Shinichi Kitajima, Michiyo Higashi, Masahiko Osako, Michiko Horinouchi, Seiya Yokoyama, Sho Kitamoto, Norishige Yamada, Yukihiro Tamura, Takeshi Shimizu, Mineo Tabata and Masamichi Goto: A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach. Gastric Cancer, 2012,  DOI: 10.1007/s10120-011-0125-2, PMID: 22237656

Michiyo Higashi, Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Kazuhiro Tabata, Chihaya Koriyama, Surinder K. Batra and Suguru Yonezawa; Pathobiological implications of expression of MUC16/CA125 in intrahepatic cholangiocarcinoma-mass forming type. Pathobiology, 79(2): 101-106, 2012, DOI: 10.1159/000335164, PMID: 22286058

Sho Kitamoto, Norishige Yamada, Seiya Yokoyama, Izumi Houjou, Michiyo Higashi, Masamichi Goto, Surinder K. Batra and Suguru Yonezawa; DNA methylation and histone H3-K9 modifications contribute to MUC17 expression. Glycobiology, 21(2):247-56, 2011, DOI: 10.1093/glycob/cwq155, PMID: 20926598 / Summary

Norishige Yamada, Yukari Nishida, Seiya Yokoyama, Hideaki Tsutsumida, Izumi Houjou, Sho Kitamoto, Masamichi Goto, Michiyo Higashi and Suguru Yonezawa; Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells. J. Hepatobiliary Pancreat Sci., 17 (6): 844-854, 2010, DOI: 10.1007/s00534-010-0278-0, PMID: 20734208
 

Sho Kitamoto, Norishige Yamada, Seiya Yokoyama, Izumi Houjou, Michiyo Higashi and Suguru Yonezawa; Promoter hypomethylation contributes to the expression of MUC3A in cancer cells. Biochem Biophys Res Commun., 397:333-9, 2010, DOI: 10.1016/j.bbrc.2010.05.124, PMID: 20510874 / Summary

Reviews 
東美智代、横山勢也、北本祥、米澤傑:胆管内乳頭状腫瘍(IPNB):粘液, MUC発現からのアプローチ、肝胆膵 65 (3) : 487-494, 2012

米澤傑、東美智代、横山勢也、北本祥、山田宗茂:癌におけるムチンの臨床 病理学的意義および診断への応用-難治性膵胆管癌の早期診断におむけて-、MEDICAL TECNOLOGY, 40(4):419-425, 2012

Suguru Yonezawa, Michiyo Higashi, Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Shin-ichi Kitajima and Masamichi Goto; Mucins in human neoplasms: Clinical pathology, gene expression and diagnostic application. Pathology International 61(12):697-716, 2011, DOI: 10.1111/j.1440-1827.2011.02734.x, PMID: 22126377  

Norishige Yamada, Sho Kitamoto, Seiya Yokoyama, Tomofumi Hamada, Masamichi Goto, Hideaki Tsutsumida, Michiyo Higashi and Suguru Yonezawa; Epigenetic regulation of mucin genes in human cancers. Clinical Epigenetics, 2(2):85-96, 2011, DOI: 10.1007/s13148-011-0037-3, PMID: 22704331

米澤傑、東美智代、山田宗茂北本祥、横山勢也、有坂好史、高折恭一;IPMNの組織亜型と分化発育 (特集:膵嚢胞性疾患の新展開)、肝胆膵 61 (3) アークメディア, p343-358, 2010

Other Publications 
米澤傑、山田宗茂、横山勢也、北本祥、田畑和宏、東美智代:第2部 病理診断医になじみのある疾患関連分子「MUC(腫瘍等)解説編・診断編」、病理と臨床、2011年臨時増刊号 (29巻) 328-340, 2011 

Suguru Yonezawa, Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Michiyo Higashi and  Masamichi Goto; MUC2 (mucin 2, oligomeric mucus/gel-forming) Atlas of Genetics and Cytogenetics in Oncology and Haematology, Published online 2009 
URL: http://atlasgeneticsoncology.org/Genes/MUC2ID41457ch11p15.html


Yuki Kariya, JiuPian Yang, Sho Kitamoto, Shuhei Hashiguchi,  and Kazuhisa Sugimura; Analysis of Sugar-Binding Peptide Motifs of Influenza H5 Hemagglutinin Using Phage-Display Library. Peptide Science 2009. Protein Research Foundation, 53, 2009

杉村和久、吉永圭介、久保田俊也、北本祥、橋口周平 ; Beyond Antibody という研究領域. Pharma Vision News No.12: 2-7, 2009, Download PDF : http://bukai.pharm.or.jp/bukai_vision/news/no_12.pdf

Shuhei Hashiguchi, Mayumi Yamamoto, Sho Kitamoto, Toshihiro Nakashima, Hitoki Yamanaka, Daisuke Ishibashi, Suehiro Sakaguchi, Shigeru Katamine, Yuji Ito,  and Kazuhisa Sugimura; Prion-conformation-specific human antibodies established from phage display library. Prions : Food and Drug Safety (Ed.T.Kitamoto)., Springer, 191-192, 2005

Links

1. Fujita Lab./藤田研究室 ; 北海道大学 遺伝病制御研究所 分子腫瘍分野
2. Yonezawa Lab./米澤研究室 ; 鹿児島大学大学院 医歯学総合研究科 人体がん病理学
3. Sugimura Lab./杉村研究室 ; 鹿児島大学大学院 理工学研究科 生体工学

Pictures

Oct 2010 @ Kirishima (with Dr. Hamasaki, R)
Mar 2009 @ Prague (with Dr. Tanaka, R)

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